@article{Itti_etal97hbm1,
  author = {L. Itti and L. Chang and J. F. Mangin and J. Darcourt and T. Ernst},
  title = {Robust multimodality registration for brain mapping},
  journal = {Human Brain Mapping},
  volume = {5},
  number = {1},
  pages = {3-17},
  year = {1997},
  keywords = {multimodality registration ; neuroimaging ; brain ; chamfer matching ; brain surface ; image processing},
  abstract = {We present a robust intrasubject registration method for the synergistic use of multiple neuroimaging modalities, with applications to magnetic resonance imaging (MRI), functional MRI, perfusion MRI, MR spectroscopy, and single-photon emission computed tomography (SPECT). This method allows user-friendly processing of difficult examinations (low spatial resolution, advanced pathology, motion during acquisition, and large areas of focal activation). Registration of three-dimensional (3D) brain scans is initially estimated by first-order moment matching, followed by iterative anisotrophic chamfer matching of brain surfaces. Automatic brain surface extraction is performed in all imaging modalities. A new generalized distance definition and new specific methodologies allow registration of scans that cover only a limited range of brain surface. A new semiautomated supervision scheme allows fast and intuitive corrections of possible false automatic registration results. The accuracy of the MRI/SPECT anatomical-functional correspondence obtained was evaluated using simulations and two difficult clinical populations (tumors and degenerative brain disorders). The average discrimination capability of SPECT (12.4 mm in-plane resolution, 20 mm slice thickness) was found to be better than 5 mm after registration with MRI (5 mm slice thickness). Registration accuracy was always better than imaging resolution. Complete 3D MRI and SPECT registration time ranged between 6-11 min, in which surface matching represented 2-3 min. No registration failure occurred. In conclusion, the application of several new image processing techniques allowed efficient and robust registration.},
  file = {http://iLab.usc.edu/publications/doc/Itti_etal97hbm1.pdf},
  type = {mip},
  if = {1998 impact factor: 4.738}
}