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O. Speck, L. Chang, L. Itti, E. Itti, T. Ernst, Comparison of static and dynamic MRI techniques for the measurement of regional cerebral blood volume, Magnetic Resonance in Medicine, Vol. 41, No. 6, pp. 1264-8, Jun 1999. [2000 impact factor: 3.121] (Cited by 20)
Abstract: Two different acquisition and processing strategies to determine the regional cerebral blood volume (rCBV) with magnetic resonance imaging (MRI) are compared. The first method is based on the acquisition of the signal time course during a bolus administration of a contrast agent (dynamic method). The second method evaluates signal changes before and after the contrast agent injection (static method), assuming the contrast agent remains primarily intravascular in the brain after the first pass. Both methods were applied to the same data sets, acquired with either echoplanar imaging (EPI, n = 18) or fast low-angle shot (FLASH, n = 28) techniques. A voxel-by-voxel correlation between the static and dynamic method yielded a correlation coefficient of 0.76 +/- 0.06 for the EPI and 0.71 +/- 0.10 for the FLASH measurements. The static method was less sensitive and showed higher standard deviations for rCBV than the dynamic method. With the development of truly intravascular contrast agents, the static perfusion MRI method, which can be performed with higher signal-to-noise ratio and higher spatial resolution, may become an alternative to ultra-fast MRI for measuring rCBV.
Keywords: Brain/*anatomy and histology/blood supply ; Cerebrovascular Circulation/*physiology ; Comparative Study ; Contrast Media ; Echo-Planar Imaging/methods ; Gadolinium DTPA/diagnostic use ; Human ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/*methods ; Support, Non-U.S. Gov't ; Support, U.S. Gov't, P.H.S. ; 2000/06/20 09:00
Themes: Medical Image Processing, Functional Neuroimaging
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