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P. Tseng, I. G. M. Cameron, D. P. Munoz, L. Itti, Differentiating patients from controls based on correlation between salience and gaze, In: Proc. Vision Science Society Annual Meeting (VSS08), May 2008.
Abstract: Several studies have shown that eye movements and certain complex visual functions are influenced by diseases such as Parkinson's Disease (PD) and Attention Deficit Hyperactivity Disorder (ADHD). Here we examine how bottom-up (stimulus-driven) attentional selection mechanisms may differ between patient and control populations, and we take advantage of the difference to develop classifiers to differentiate patients from controls. We tracked gaze of four groups of observers (15 control children, aged 7-14; 6 ADHD children, aged 9-15; 12 control elderly, aged 66-79; and 9 PD elderly, aged 53-68) while they freely viewed MTV-style videos. These stimuli are composed of short (2-4 seconds), unrelated clips of natural scenes to reduce top-down (contextual) expectations and emphasize bottom-up influences on gaze allocations at the scene change. We used a saliency model to compute bottom-up saliency maps for every video frame. Saliency maps can be computed from a full set of features (color, intensity, orientation, flicker, motion) or from individual features. Support-vector-machine classifiers (with Radial-Basis Function Kernel) were built for each feature contributing the saliency map and for the combination of them. Leave-one-out was used to train and test the classifiers. Two classification experiments were performed: (1) between ADHD and control children; (2) between PD and control elderly. Saliency maps computed with all features can well differentiate patients and control populations (correctness: experiment 1 - 100%; experiment 2 - 95.24%). Additionally, saliency maps computed from any one feature performed nearly as well (both experiments' results are 0-5% worse). Moreover, 0-250 ms after scene change is the most discriminative period for the classification. This study demonstrates that the bottom-up mechanism is greatly influenced by PD and ADHD, and the difference can serve as a probable diagnosis tool for clinical applications.
Themes: Model of Bottom-Up Saliency-Based Visual Attention, Model of Top-Down Attentional Modulation, Computational Modeling, Human Psychophysics, Medical Research
Copyright © 2000-2007 by the University of Southern California, iLab and Prof. Laurent Itti.
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