Abstract


= PDF Reprint,     = BibTeX entry,     = Online Abstract


Click to download PDF version Click to download BibTeX data Clik to view abstract P. Tseng, I. G. M. Cameron, G. Pari, J. N. Reynolds, D. P. Munoz, L. Itti, High-throughput classification of clinical populations from natural viewing eye movements, Journal of Neurology, Vol. 260, pp. 275-284, Jan 2013. [2011 Impact Factor: 3.473] (Cited by 54)

Abstract: Many high-prevalence neurological disorders involve dysfunctions of oculomotor control and attention, including attention deficit hyperactivity disorder (ADHD), fetal alcohol spectrum disorder (FASD), and Parkinson's disease (PD). Previous studies have examined these deficits with clinical neurological evaluation, structured behavioral tasks, and neuroimaging. Yet, time and monetary costs prevent deploying these evaluations to large at-risk populations, which is critically important for earlier detection and better treatment. We devised a high-throughput, low-cost method where participants simply watched television while we recorded their eye movements. We combined eyetracking data from patients and controls with a computational model of visual attention to extract 224 quantitative features. Using machine learning in a workflow inspired by microarray analysis, we identified critical features that differentiate patients from control subjects. With eye movement traces recorded from only 15 min of videos, we classified PD versus age-matched controls with 89.6% accuracy (chance 63.2%), and ADHD versus FASD versus control children with 77.3% accuracy (chance 40.4%). Our technique provides new quantitative insights into which aspects of attention and gaze control are affected by specific disorders. There is considerable promise in using this approach as a potential screening tool that is easily deployed, low-cost, and high-throughput for clinical disorders, especially in young children and elderly populations who may be less compliant to traditional evaluation tests.

Themes: Human Eye-Tracking Research, Medical Research, Computational Modeling, Human Psychophysics

 

Copyright © 2000-2007 by the University of Southern California, iLab and Prof. Laurent Itti.
This page generated by bibTOhtml on Wed Feb 15 12:13:56 PST 2017